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yrkP [2019-08-28 12:30:52]
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yrkP [2019-08-28 12:30:52]

two-component response regulator ([SW|OmpR family])
locus
BSU_26430
pI
5.69
mw
26.65 kDa
protein length
231 aa Sequence Blast
gene length
696 bp Sequence Blast
function
unknown
product
two-component response regulator ([SW|OmpR family])
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • Gene

    Coordinates
    2,704,435 2,705,130

    The protein

    Protein family

  • [SW|OmpR family] of two-component response regulators

    • Modification

  • phosphorylated by [protein|8A38FEFAA0FF91D989B77D40CBB3741902DC9D67|YrkQ] on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • Structure

  • [PDB|2OQR] (RegX3 from Mycobacterium tuberculosis, 38% identity) [pubmed|17942407]

    • additional information

  • information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000233 PRODORIC2 database]

    • Expression and Regulation

    Operons

    genes
    [gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]-[gene|8A38FEFAA0FF91D989B77D40CBB3741902DC9D67|yrkQ]-[gene|E0DF6DE230AD0B632EEC0A1FB11EB32E59BD573E|yrkR]
    description
    [Pubmed|18175906]

    regulatory mechanism

  • [protein|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|YrkP]: activation, [Pubmed|18175906], in [regulon|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|YrkP regulon]
    • view in new tab

    Biological materials

    Mutant

  • BKE26430 ([gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE26430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCTCTCACCTCATG, downstream forward: _UP4_CGATTTGGCGCATCTTAAAT
  • BKK26430 ([gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK26430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCTCTCACCTCATG, downstream forward: _UP4_CGATTTGGCGCATCTTAAAT

    • References

  • 10094672,18175906,23504016,17942407